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Full text of "USPTO Patents Application 10068965"

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wo 01/11038 



PCT/EPOO/07731 



Figure 1. 



1/11 



LDL' Choi (mg/dl): 0 100 200 
CAV-1 IB 

eNOS IB 
CAV-1 IP/ eNOS IB 



wo 01/11038 



PCT/EPOO/07731 



CI 

m 



Figure 2A. 



2/11 



a 
m 
m 
m 
m 
111 



A. 



Atorva statin (jiM) 
0 0.01 0.1 1 10 



LDL- 

Chol 100 ^m^mmmmm.^ 

(mg/df) 

''^r nTiim ^ ,1111 I 
CAV-1 IB 



Atorvastatin (jjM) 
0 0.01 0.1 1 10 



eNOS IB 



wo 01/11038 



PCT/EPOO/07731 



3/11 

Figure 2B. 




wo 01/11038 



PCTAEPOO/07731 



4/11 

Figure 3. 



LDL-Cho l: 0 100 200 
Atorva. L + + - + J 

ALUi - + ^ 

MevaL - + + + + 

I 

CAV-1 IB 



wo 01/11038 



PCT/EPOO/07731 



Rgure4A. ^^^^ 



Atorva. (pM) 



0 0.1 

CAV-1 IP/ eNOS IB mmm mmm 

CAV-1 IP Spnt 

eNOS IP/ eNOS IB — • 



wo 01/11038 



Figure 4B. 



6/11 



PCT/EPOO/07731 



czzjCaveolln-depleted lysates 



175- 
150- 


■BiTotaflysates 

§ 


* 


* 


125- 
<00- 
7S- 


nl 


§ 

pi 


1 






0 0.1 





Atorvastatin (jiM) 



wo 01/11038 



Rgure 5A. 



7/11 



PCT/EPOO/07731 



EE^LOL-Chol 100 mg/di 




[Atorvastatin] OiM) 



wo 01/11038 



Figure 5B. 



8/11 



PCT/EPOO/07731 



I No treatment 




LDL-Chol (mg/dl) 



wo 01/11038 



Figure SC. 



9/11 



PCT/EPOO/07731 




. 0 100 20O 

LDL-Cfaol (mg/dl) 



wo 01/11038 



PCT/EPOO/07731 



10/11 

Figure 6. 



LDL-Chol 0 LDL-Chol 200 

I II 1 

A23187(5fjM}: -- + + -- + + 

Atorvastatin (IfjM): .+.+- + _ + 
eNOS IP/ 

HspOOlB ^ mm mv — 



Hsp90 IB 



wo 01/11038 



PCT/EPOO/07731 



Figure 7: 



11/11